## WHO MDT Regimen for Paucibacillary Leprosy **Key Point:** The WHO standard MDT regimen for paucibacillary (PB) leprosy consists of a 6-month course of supervised therapy. ### Composition of PB-MDT | Drug | Dose | Frequency | | --- | --- | --- | | Rifampicin | 600 mg | Monthly (supervised) | | Dapsone | 100 mg | Daily (self-administered) | | Clofazimine | 300 mg | Monthly (supervised) + 50 mg daily | ### Duration and Supervision 1. **Total duration:** 6 months of therapy 2. **Supervised doses:** Monthly rifampicin and clofazimine (6 doses) 3. **Self-administered:** Daily dapsone and clofazimine between supervised visits 4. **Completion criterion:** Patient is considered cured after completing 6 monthly supervised doses **High-Yield:** Paucibacillary leprosy includes tuberculoid leprosy (TT) and borderline tuberculoid (BT) forms, which have low bacillary load and hence shorter MDT duration. **Clinical Pearl:** Patients are considered non-infectious after the first monthly supervised dose of rifampicin, allowing them to return to work and social activities. **Mnemonic:** PB = "6 months" (Paucibacillary = shorter duration); MB = "12 months" (Multibacillary = longer duration). [cite:Park 26e Ch 9] 
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