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Subjects/Medicine/Medicine
Medicine
medium
stethoscope Medicine

Which of the following is not a characteristic feature of multiple myeloma?

A. Increased Ig levels in serum
B. Positive ANA
C. Plasmacytosis
D. M spike on electrophoresis

Explanation

Ans. B. Positive ANASerum electrophoresis: Abnormal spike in the region of gamma globulin (myeloma spike) is present in 90% of cases.* Bone marrow plasmacytosis in multiple myeloma is characteristically more than 30%.* The immunoglobulin least commonly involved in Multiple Myeloma is IgD.* The immunoglobulin most commonly involved in Multiple Myeloma is IgG. - Low haemoglobin, - high ESR (usually very high), - increased total protein, - A/G ratio reversed, - increased serum calcium, - normal alkaline phosphatase. - Urine: Bence Jones proteins are found in 30% of cases.

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