Ans. b. The unionized fraction of calcium in the plasma is an impoant determinant of PTH secretion"Circulating ionized calcium acts directly on the parathyroid glands in a negative feedback fashion to regulate the secretion of PTH."Magnesium is required to maintain normal parathyroid secretory responses. Impaired PTH release along with diminished target responses to PTH account fir the hypocalcaemia that occasionally occurs in magnesium deficiency
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