## IPV Administration in NIS **Key Point:** The first dose of Inactivated Polio Vaccine (IPV) is administered at **6 weeks of age** as per the current National Immunisation Schedule of India. ### Schedule Timeline IPV is given at the following ages: - **1st dose:** 6 weeks - **2nd dose:** 10 weeks - **3rd dose:** 14 weeks - **Booster dose:** 18–24 months **High-Yield:** IPV replaced OPV (Oral Polio Vaccine) as the primary polio vaccine in the NIS to achieve polio elimination and prevent vaccine-derived poliovirus (VDPV) transmission. India was declared polio-free in 2014. ### Rationale for Early Immunisation Polio vaccination begins at 6 weeks because: - Maternal antibodies wane by this age - Early seroconversion is achievable - Three primary doses ensure adequate immunity before 18 months **Clinical Pearl:** The schedule follows a 4-week interval between primary doses (6, 10, 14 weeks) to allow optimal immune response and antibody development.
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