A 35-year-old man with biopsy-proven minimal change disease (MCD) presents with nephrotic syndrome (proteinuria 7 g/day, serum albumin 2.3 g/dL, serum creatinine 0.9 mg/dL). He is started on prednisolone 1 mg/kg/day. After 6 weeks of therapy, proteinuria remains 5.5 g/day and edema persists. What is the most appropriate next step?

See the options, answer & explanation

Sign in free to reveal the answer choices, the correct answer, the detailed explanation, and AI-powered insights for this question.