## NPCDCS Blood Pressure Targets in High-Risk Populations **Key Point:** For patients with diabetes and/or chronic kidney disease, the NPCDCS guideline recommends a target blood pressure of < 130/80 mmHg to reduce cardiovascular and renal complications. ### Rationale for Stricter BP Control **High-Yield:** Patients with diabetes and CKD have significantly elevated cardiovascular and renal risk. Stricter BP control (< 130/80 mmHg) has been shown to: - Slow progression of diabetic nephropathy - Reduce proteinuria and albuminuria - Lower cardiovascular event rates - Prevent end-stage renal disease (ESRD) ### NPCDCS Blood Pressure Target Categories | Population Group | Target BP | Rationale | | --- | --- | --- | | General population (no comorbidities) | < 140/90 mmHg | Standard hypertension control | | Diabetes OR CKD (alone) | < 130/80 mmHg | High cardiovascular/renal risk | | Diabetes AND CKD | < 130/80 mmHg | Very high risk; aggressive control | | Post-MI or heart failure | < 130/80 mmHg | Secondary prevention | **Clinical Pearl:** The NPCDCS aligns with international guidelines (ACC/AHA 2017, ESC 2018) that advocate for lower BP targets in high-risk patients. However, individual tolerance and adverse effects must be monitored. **Mnemonic:** **D-CKD Rule** = **D**iabetes or **C**hronic **K**idney **D**isease → target 130/80 (not 140/90). [cite:Park 26e Ch 10]
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