NSAIDs — COX-1 vs COX-2 Selectivity MCQ — NEET PG Practice Question | NEETPGAI
NSAIDs — COX-1 vs COX-2 Selectivity
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pill Pharmacology
A 58-year-old man with osteoarthritis and a history of myocardial infarction 2 years ago presents with chronic knee pain. His physician is considering NSAIDs for pain management. The structure marked **C** in the diagram represents COX-2 selective inhibitors (celecoxib, etoricoxib). Which of the following best explains why COX-2 selective inhibitors, despite their reduced gastrointestinal toxicity, carry an increased cardiovascular risk compared to non-selective NSAIDs?
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