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Subjects/Ophthalmology/Ophthalmology
Ophthalmology
medium
eye Ophthalmology

Which of the following stain is used for diagnosis of Granular dystrophy of cornea?

A. Colloidal iron
B. Congo red
C. PAS
D. Masson trichrome

Explanation

Ans: D. Masson trichrome(Ref: Kanski 7/e p212-224; Parson :s 22/e p212-214, 21/e p207-209; Yanoff and Duker 4/e p261).Masson trichrome stain - Used for granular corneal dystrophy diagnosis.Granular dystrophy:AD inheritance with gene locus on 5q31Onset: First decade with recurrent erosionsSigns (in chronological order):Small, white, sharply demarcated deposits resembling crumbs or snowflakes in central anterior stroma.Increasing number of lesions with deeper & outward spread but not reaching limbus.Gradual confluence causing visual acuity impairment.Histology:Shows amorphous hyaline deposits staining bright red with Masson trichrome.

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