Naloxone is a pure opioid antagonist that rapidly reverses the effects of opioid overdose, particularly respiratory depression and central nervous system depression. It is the drug of choice for immediate management of suspected opioid overdose. Flumazenil is a benzodiazepine antagonist. Activated charcoal may be used for oral ingestions but is not the primary intervention for respiratory depression in an unresponsive patient. Lorazepam is a benzodiazepine and would further depress the central nervous system, worsening the patient's condition.
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