Naltrexone is an opioid antagonist that blocks opioid receptors, thereby preventing the euphoric and sedative effects of opioids. It is used for the long-term maintenance treatment of OUD and can be administered orally or as an extended-release injectable. Methadone and buprenorphine are opioid agonists (full and partial, respectively) used in Medication-Assisted Treatment (MAT) for OUD, but they work by reducing cravings and withdrawal symptoms, not by blocking opioid effects as an antagonist. Disulfiram is used for alcohol use disorder.
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