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Subjects/Pathology/Pathology
Pathology
medium
microscope Pathology

Translocation seen in Ewing's sarcoma is:

A. t(8,11)
B. t(11,22)
C. t(11,18)
D. t(14,18)

Explanation

Ans: B. t(11,22)Genetic exchange between chromosomes can cause cells to become cancerous. Most cases of Ewing's sarcoma (85%) are the result of a translocation between chromosomes 11 and 22, which fuses the EWS gene of chromosome 22 to the FLI1 gene of chromosome 11. Other translocations are at t(21;22) and t(7;22).

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