Ans. A. ADHOsmolarity and volume status are the two greatest factors that affect ADH secretion.However, a variety of other factors promote ADH secretion as well.These include angiotensin II, pain, nausea, hypoglycemia, nicotine, opiates, and ceain medications.ADH secretion is also negatively affected by ethanol, alpha-adrenergic agonists, and atrial natriuretic peptide.Ethanol's inhibitory effect helps to explain the increased diuresis experienced during intoxicated states as well as increased free water loss; without appropriate ADH secretion, more water is excreted by the kidneys.
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