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Subjects/Physiology/Physiology
Physiology
medium
heart-pulse Physiology

Interstitial fluid volume can be determined by:

A. Radioactive iodine and radiolabelled water
B. Radioactive water and radiolabelled albumin
C. Radioactive sodium and radioactive water
D. Radioactive sodium and radioactive labelled albumin

Explanation

Ans: D. Radioactive sodium and radioactive labelled albumin(Ref Ganong 25/e p3, 24/e p2; Guvton I p309, 310)Fluid volumeIndicator usedTotal body water volumeDeuterium oxide: D20 (MC used)degTritium oxidedeg, Aminopyrinedeg, AntipyrinedegExtracellular fluid volumeInulin (most accurate)degs22Na, 1251-iothalamate, thiosulfatedegPlasma volumeEvans bluedegSerum albumin labeled with radioactive iodinedeg (1-125)Intracellular fluid(Calculated as total body water - extracellular fluid volume)Blood volume"Cr-labeled RBCsdeg, or calculated as blood volume = plasma volume/ (1 - hematocrit)Interstitial fluid(Calculated as extracellular fluid volume - plasma volume)

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