Bilateral, symmetrical pleural effusions, especially in the context of congestive heart failure (CHF) and cardiomegaly, are highly suggestive of a transudative effusion. Transudates are typically caused by systemic factors altering hydrostatic or oncotic pressures (e.g., CHF, cirrhosis, nephrotic syndrome). Exudates are usually due to local pleural inflammation or disease (e.g., infection, malignancy, autoimmune disease) and are often unilateral or asymmetrical. Chylothorax (lymphatic fluid) and hemothorax (blood) have specific causes and often distinct imaging features (though not always on plain film) or clinical presentations.
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