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    Subjects/OBG/Pregnancy-Induced Hypertension
    Pregnancy-Induced Hypertension
    hard
    baby OBG

    Regarding the clinical features, diagnostic criteria, and management of gestational hypertension and preeclampsia, all of the following statements are correct EXCEPT:

    A. Severe preeclampsia requires systolic BP ≥160 mmHg or diastolic BP ≥110 mmHg on two occasions at least 4 hours apart
    B. Pulmonary edema in preeclampsia is primarily due to decreased plasma oncotic pressure from severe proteinuria
    C. Gestational hypertension is defined as hypertension first detected after 20 weeks of gestation without proteinuria or other features of preeclampsia
    D. Delivery is the definitive treatment for preeclampsia and should be offered at ≥34 weeks of gestation regardless of maternal or fetal condition

    Explanation

    ## Gestational Hypertension and Preeclampsia: Definitions, Diagnosis, and Management ### Definition of Gestational Hypertension **Key Point:** Gestational hypertension is defined as new-onset hypertension (BP ≥140/90 mmHg) first detected after 20 weeks of gestation **without proteinuria or other clinical/laboratory features of preeclampsia** [cite:ACOG Guidelines on Hypertension in Pregnancy]. ### Diagnostic Criteria for Severe Preeclampsia **High-Yield:** Severe preeclampsia is diagnosed when **systolic BP ≥160 mmHg OR diastolic BP ≥110 mmHg on two occasions at least 4 hours apart** (or one reading ≥180/120 mmHg if urgent intervention is needed), OR when preeclampsia is accompanied by severe features (severe headache, visual disturbances, epigastric pain, pulmonary edema, thrombocytopenia <100,000/μL, elevated liver enzymes, acute kidney injury) [cite:ACOG Guidelines 2017]. ### Pulmonary Edema in Preeclampsia: Mechanism **Clinical Pearl:** The mechanism of pulmonary edema in preeclampsia is **NOT primarily decreased plasma oncotic pressure** (though severe proteinuria does occur). Instead, pulmonary edema in preeclampsia is caused by: 1. **Increased capillary permeability** due to endothelial dysfunction 2. **Decreased plasma oncotic pressure** (secondary to proteinuria) — a minor contributor 3. **Left ventricular dysfunction** and increased pulmonary capillary wedge pressure 4. **Fluid overload** from aggressive IV hydration or oliguric renal failure **Warning:** The primary mechanism is endothelial dysfunction and increased capillary permeability, NOT oncotic pressure alone. This is a common misconception. ### Timing of Delivery in Preeclampsia **High-Yield:** Delivery is the definitive treatment for preeclampsia, BUT the timing is **NOT uniform**. Current guidelines recommend: | Gestational Age | Maternal Condition | Fetal Status | Recommendation | |---|---|---|---| | <34 weeks | Stable | Reassuring | Expectant management with corticosteroids for fetal lung maturity | | <34 weeks | Severe features | Any | Delivery after corticosteroids (if time permits) | | ≥34 weeks | Any | Any | Delivery is recommended [cite:ACOG 2017] | | ≥37 weeks | Any | Any | Delivery is recommended | **Key Point:** Delivery at ≥34 weeks is recommended, but **NOT "regardless of maternal or fetal condition."** If the mother is stable and the fetus is reassuring at <34 weeks, expectant management with close monitoring and corticosteroids is appropriate. Delivery should be individualized based on severity of preeclampsia, maternal symptoms, fetal well-being, and gestational age [cite:ACOG 2017]. ### Summary Table: Gestational Hypertension vs Preeclampsia | Feature | Gestational HTN | Preeclampsia | Severe Preeclampsia | |---------|---|---|---| | Onset | >20 weeks | >20 weeks | >20 weeks | | BP criteria | ≥140/90 mmHg | ≥140/90 mmHg | ≥160/110 mmHg | | Proteinuria | Absent | Present (≥0.3 g/24 h) | Often present | | Severe features | None | May have | Must have ≥1 | | Maternal risk | Low | Moderate–high | High | | Delivery timing | At term | ≥37 weeks (or earlier if severe) | ≥34 weeks (or earlier if unstable) | **Mnemonic:** **SEVERE** features of preeclampsia = **S**ystolic BP ≥160, **E**pigastric pain, **V**isual disturbances, **E**levated liver enzymes, **R**enal dysfunction, **E**clampsia or pulmonary edema [cite:ACOG 2017].

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