A 52-year-old man from Delhi presents with recurrent acute gout attacks affecting the first metatarsophalangeal joint. Laboratory investigations show serum uric acid 9.2 mg/dL and 24-hour urinary uric acid excretion 1100 mg/day (normal <800 mg/day). Regarding the biochemical basis of hyperuricemia and urate-lowering therapy, all of the following are true EXCEPT:

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