A 52-year-old man with a 10-year history of gout presents with acute podagra. Serum uric acid is 8.2 mg/dL. Urine uric acid is 450 mg/day (normal <600 mg/day). A 45-year-old woman with similar serum uric acid presents with recurrent nephrolithiasis. Her 24-hour urine uric acid is 1200 mg/day. Which feature best distinguishes the underexcretor phenotype of gout from the overproducer phenotype?

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