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    Subjects/Physiology/Renin-Angiotensin-Aldosterone System (RAAS)
    Renin-Angiotensin-Aldosterone System (RAAS)
    medium
    heart-pulse Physiology

    A 52-year-old man with chronic kidney disease (CKD stage 3b) presents with hypertension refractory to two antihypertensive agents. Serum creatinine is 2.8 mg/dL, and urinalysis shows proteinuria. Plasma renin activity is markedly elevated. Which is the most common pathophysiological mechanism underlying secondary hypertension in this patient?

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