A 35-year-old man from rural Maharashtra presents to the emergency department 18 hours after consuming wild mushrooms foraged from his garden. He reports severe vomiting and profuse watery diarrhea that began 8 hours post-ingestion. Abdominal examination is unremarkable. Liver function tests are currently normal. The structure marked **B** in the diagram is the primary molecular target of the toxin responsible for this patient's presentation. Which of the following best describes the mechanism by which this toxin causes hepatocellular injury in amanita poisoning?