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    Subjects/Psychiatry/Schizophrenia — Clinical Features
    Schizophrenia — Clinical Features
    medium
    brain Psychiatry

    A 32-year-old woman with a 5-year history of schizophrenia is being evaluated for persistent symptoms despite antipsychotic therapy. Which of the following is the most common negative symptom in schizophrenia?

    A. Avolition (lack of motivation)
    B. Anhedonia (inability to experience pleasure)
    C. Alogia (poverty of speech)
    D. Affective flattening (restricted emotional expression)

    Explanation

    Most Common Negative Symptom in Schizophrenia

    Key Point
    Affective flattening (restricted range and intensity of emotional expression) is the most frequently observed negative symptom in schizophrenia, present in the majority of patients.
    Prevalence and Characteristics of Negative Symptoms
    Table
    Negative SymptomFrequencyDefinitionClinical Presentation
    Affective flattening60–80%Restricted emotional expressionBlunted facial expressions, monotone voice, minimal gesturing
    Avolition40–60%Lack of motivation and driveApathy, poor hygiene, inability to initiate activities
    Alogia30–50%Poverty of speechBrief, laconic responses; reduced spontaneous speech
    Anhedonia30–50%Loss of pleasure capacityDiminished interest in activities, social withdrawal
    Affective Flattening: Core Features
    High-YieldNEET PG
    Affective flattening is characterized by:
    1. 1.
      Reduced facial expressivity — unchanging facial appearance despite emotional stimuli
    2. 2.
      Monotone or restricted prosody — flat, emotionless voice quality
    3. 3.
      Decreased gesturing — minimal hand and body movements during speech
    4. 4.
      Reduced eye contact — avoidance or minimal engagement
    Clinical Pearl
    Affective flattening is one of the earliest and most persistent negative symptoms, often present before the onset of positive symptoms and continuing after their remission. It is a core feature of the deficit syndrome in schizophrenia.
    Warning
    Do not confuse affective flattening with depression or medication-induced parkinsonism (which can mimic restricted affect). Affective flattening in schizophrenia is primary and reflects the underlying pathophysiology, whereas secondary causes should be ruled out.

    Mnemonic: AAAA — Affective flattening, Alogia, Avolition, Anhedonia (the "four A's" of negative symptoms). Affective flattening is the most common.

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