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Subjects/Dermatology/Seborrheic Dermatitis
Seborrheic Dermatitis
medium
hand Dermatology

A 28-year-old patient is diagnosed with mild to moderate seborrheic dermatitis affecting the scalp and face. Which of the following topical agents would be the most appropriate first-line treatment?

A. A. Topical calcineurin inhibitors (e.g., tacrolimus)
B. B. High-potency topical corticosteroids (e.g., clobetasol)
C. C. Topical antifungal agents (e.g., ketoconazole)
D. D. Topical retinoids (e.g., tretinoin)

Explanation

Given the strong association of *Malassezia* species with seborrheic dermatitis, topical antifungal agents like ketoconazole, ciclopirox, or selenium sulfide are considered first-line treatments. They reduce the yeast population and subsequent inflammation. Mild topical corticosteroids can be used for short periods to control inflammation but are not ideal for long-term monotherapy due to potential side effects. Topical calcineurin inhibitors are second-line options, and topical retinoids are generally not used for seborrheic dermatitis.

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