A 32-year-old woman with established SLE (ANA+, anti-dsDNA+) presents with acute-onset severe headache, confusion, and photophobia. Vital signs show fever (38.5°C) and blood pressure 158/98 mmHg. Fundoscopy reveals retinal hemorrhages and cotton-wool spots. CSF analysis shows pleocytosis (WBC 120/μL, predominantly lymphocytes) with normal glucose and protein. Which investigation is most appropriate to differentiate lupus cerebritis from meningitis?

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