## Spinothalamic Tract — Anatomy and Crossed Sensory Loss **Key Point:** The spinothalamic tract carries pain and temperature sensation and decussates at the **spinal cord level** (1–2 segments above entry). A lesion on one side causes **contralateral** loss of pain/temperature **below** the lesion. ### Anatomical Organization ```mermaid flowchart TD A[Peripheral nociceptor/thermoreceptor]:::outcome --> B[First-order neuron enters dorsal root]:::outcome B --> C[Synapse in dorsal horn at same level]:::outcome C --> D[Second-order neuron decussates 1-2 segments above entry]:::action D --> E[Ascend contralaterally as spinothalamic tract]:::action E --> F[VPL thalamus]:::outcome F --> G[Primary sensory cortex]:::outcome ``` ### Clinical Correlation: Right T5 Lesion | Finding | Explanation | | --- | --- | | **Lesion side** | Right T5 | | **Sensory loss side** | Left (contralateral) | | **Sensory modality** | Pain and temperature | | **Level of loss** | T7–T8 and below (2–3 segments below lesion) | | **Reason for offset** | Decussation occurs 1–2 segments above the entry level | **High-Yield:** Right-sided spinal cord lesion → **left-sided pain/temperature loss** (spinothalamic tract crosses). This is the hallmark of **Brown-Séquard syndrome** (hemisection of spinal cord). **Mnemonic:** **STT = Spinothalamic Tract crosses early** (at spinal cord, not brainstem like DCML). **Contralateral pain/temp loss below the lesion.** **Clinical Pearl:** In Brown-Séquard syndrome: - **Ipsilateral** loss of motor function and proprioception (corticospinal tract and DCML cross at brainstem) - **Contralateral** loss of pain/temperature (spinothalamic tract crosses at spinal cord) ### Why Not the Other Tracts? - **Fasciculus gracilis:** Carries proprioception (not pain/temperature) and crosses at the medulla (not spinal cord). - **Dorsal spinocerebellar tract:** Carries proprioception to cerebellum, does not cross, and does not cause sensory loss to cortex. - **Dorsal root entry zone:** Damage here would cause **ipsilateral** segmental loss at the level of injury, not contralateral loss below. 
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