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    Subjects/Physiology/Spirometry — Patterns and Interpretation
    Spirometry — Patterns and Interpretation
    medium
    heart-pulse Physiology

    A 58-year-old male smoker presents to the chest clinic with progressive dyspnea on exertion and chronic cough productive of scanty sputum for the past 3 years. On examination, he has reduced breath sounds bilaterally and prolonged expiration. Spirometry shows: FEV₁ = 52% predicted, FVC = 78% predicted, FEV₁/FVC ratio = 0.58. DLCO is reduced at 65% predicted. What is the most likely diagnosis?

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