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Subjects/Psychiatry/SSRIs
SSRIs
easy
brain Psychiatry

A 35-year-old female is prescribed fluoxetine for major depressive disorder. What is the primary mechanism of action of this medication?

A. A. Blockade of dopamine reuptake
B. B. Inhibition of serotonin reuptake
C. C. Antagonism of muscarinic acetylcholine receptors
D. D. Potentiation of GABAergic neurotransmission

Explanation

Fluoxetine is a Selective Serotonin Reuptake Inhibitor (SSRI). Its primary mechanism of action is to selectively inhibit the reuptake of serotonin (5-HT) into the presynaptic neuron. This leads to an increased concentration of serotonin in the synaptic cleft, enhancing serotonergic neurotransmission and ultimately alleviating symptoms of depression and anxiety. Other options describe mechanisms of other classes of psychotropic medications (e.g., dopamine reuptake blockade for stimulants, muscarinic antagonism for tricyclic antidepressants, GABA potentiation for benzodiazepines).

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