A 28-year-old woman develops a blistering eruption 2 weeks after starting trimethoprim-sulfamethoxazole for a urinary tract infection. Examination reveals confluent erythematous patches with central blistering on the palms, soles, and genitalia, along with oral mucosal erosions. Which single feature best distinguishes Stevens-Johnson Syndrome (SJS) from Toxic Epidermal Necrolysis (TEN) in this patient?

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