A public health researcher in Delhi conducted a study comparing the effectiveness of two different health education interventions (A and B) on reducing tobacco use among 120 factory workers. The data showed: Intervention A: 45 workers quit tobacco, 15 continued; Intervention B: 38 workers quit tobacco, 22 continued. The researcher wants to determine if there is a statistically significant difference between the two interventions. What is the most appropriate next step in analysis?