Sistrunk's operation is the standard and definitive surgical procedure for a thyroglossal duct cyst. It involves not only excising the cyst but also removing the central portion of the hyoid bone and a core of muscle and connective tissue extending from the hyoid bone up to the foramen cecum at the base of the tongue. This extensive removal is crucial to prevent recurrence, as the duct often passes through or is intimately associated with the hyoid bone. Simple excision of the cyst alone has a high recurrence rate.
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