Transcription and RNA Processing MCQ — NEET PG Practice Question | NEETPGAI
Transcription and RNA Processing
hard
flask-conical Biochemistry
A 28-year-old man from Bangalore is diagnosed with β-thalassemia major after presenting with severe hemolytic anemia, splenomegaly, and transfusion-dependent anemia since childhood. Molecular analysis reveals a mutation in the polyadenylation signal (AATAAA → AATGAA) in the 3′ untranslated region of the β-globin gene. Which of the following best explains why this mutation causes β-thalassemia despite the coding sequence being intact?
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