A 38-year-old female tailor from Mumbai presents with a 6-month history of progressive numbness and tingling in the medial 1.5 fingers of her right hand, with recent onset of a painful lump at the base of her palm on the medial side. On examination, there is a firm, tender mass palpable in the hypothenar region. Intrinsic hand muscle strength is intact, and she has no wasting. Sensation is diminished over the palmar and dorsal aspects of the medial 1.5 fingers. Which is the most likely diagnosis?

Question

Accepted Answer

C. Ulnar nerve compression at Guyon's canal due to a ganglion cyst. ## Clinical Presentation Dissection **Key Point:** A palpable mass in the hypothenar region (medial base of palm) with sensory loss in medial 1.5 fingers but preserved motor function suggests a **superficial branch compression** of the ulnar nerve at Guyon's canal. **High-Yield:** Guyon's canal is bounded by the pisiform medially, the hook of hamate laterally, and the palmaris brevis and hypothenar muscles. Ganglion cysts are the most common compressive lesion here (40–50% of Guyon's canal masses). ## Anatomical Basis: Guyon's Canal Lesions ```mermaid flowchart TD A["Ulnar nerve enters hand
medial to pisiform"]:::outcome --> B{"Splits into branches"}:::decision B -->|"Superficial branch
continues distally"| C["Sensation: palmar medial 1.5 fingers
Motor: palmaris brevis only"]:::action B -->|"Deep branch
curves around hook of hamate"| D["Motor: hypothenar, lumbricals 3-4,
interossei, adductor pollicis"]:::action E["Ganglion cyst in Guyon's canal"]:::urgent --> F["Compresses superficial branch
Spares deep branch"]:::decision F --> G["Sensory loss + preserved motor"]:::outcome ``` ## Differential: Guyon's Canal vs Cubital Tunnel | Feature | Guyon's Canal | Cubital Tunnel | |---------|---------------|----------------| | **Location of mass** | Hypothenar region (base of palm) | Medial elbow | | **Intrinsic muscle wasting** | Absent (deep branch spared) | Present (all intrinsics affected) | | **Dorsal sensation** | Preserved (dorsal cutaneous branch arises proximal) | Lost (branch arises distal) | | **Froment's sign** | Negative | Positive | | **Common cause** | Ganglion cyst, hook of hamate fracture | Cubital tunnel syndrome, trauma | | **Motor deficit** | Minimal or absent | Marked | **Clinical Pearl:** The **superficial branch** of the ulnar nerve at Guyon's canal is purely sensory (supplies medial 1.5 fingers) and motor to palmaris brevis only. Compression here causes sensory loss without significant motor deficit—a key distinguishing feature. ## Why This Is Guyon's Canal Compression 1. **Palpable mass in hypothenar region:** Ganglion cysts commonly arise from the pisotriquetral joint and compress the superficial branch at Guyon's canal. 2. **Sensory loss with intact motor:** The superficial branch (sensory) is compressed while the deep branch (motor to intrinsics) is spared. 3. **No intrinsic wasting:** Preservation of motor function to intrinsic hand muscles rules out cubital tunnel and proximal lesions. 4. **Occupation (tailor):** Repetitive wrist flexion and pressure on the palm can precipitate ganglion formation. **Mnemonic:** **SHAG** = **S**uperficial branch (Sensation), **H**ypothenars (palmaris brevis only), **A**rises at Guyon's, **G**anglion (common cause). ![Ulnar Nerve — Course and Lesions diagram](https://mmcphlazjonnzmdysowq.supabase.co/storage/v1/object/public/blog-images/explanation/4091.webp)

Answer

A. Posterior interosseous nerve syndrome

Answer

B. Median nerve compression at the carpal tunnel

Answer

D. Ulnar nerve compression at the cubital tunnel

Explanation

Clinical Presentation Dissection

Anatomical Basis: Guyon's Canal Lesions

Differential: Guyon's Canal vs Cubital Tunnel

Why This Is Guyon's Canal Compression

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Feature	Guyon's Canal	Cubital Tunnel
Location of mass	Hypothenar region (base of palm)	Medial elbow
Intrinsic muscle wasting	Absent (deep branch spared)	Present (all intrinsics affected)
Dorsal sensation	Preserved (dorsal cutaneous branch arises proximal)	Lost (branch arises distal)
Froment's sign	Negative	Positive
Common cause	Ganglion cyst, hook of hamate fracture	Cubital tunnel syndrome, trauma
Motor deficit	Minimal or absent	Marked