For healthy adults undergoing general anesthesia, initial ventilator settings typically aim for lung-protective ventilation. A tidal volume of 6-8 mL/kg ideal body weight is recommended. A respiratory rate of 10-14 bpm is common. PEEP (Positive End-Expiratory Pressure) of 3-5 cmH2O is often applied to prevent atelectasis and maintain functional residual capacity. FiO2 (Fraction of inspired oxygen) is adjusted to maintain adequate oxygen saturation, often starting around 0.4-0.5 and titrating down. Option B provides the most physiologically sound initial settings: Tidal Volume 6 mL/kg (420 mL for 70kg), Respiratory Rate 12 bpm, PEEP 5 cmH2O, and FiO2 0.4.
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