Vitamin B12 and Folate — One-Carbon Metabolism MCQ — NEET PG Practice Question | NEETPGAI
Vitamin B12 and Folate — One-Carbon Metabolism
hard
flask-conical Biochemistry
A 62-year-old Indian woman with pernicious anemia presents with megaloblastic anemia, paresthesias, and gait ataxia. Serum vitamin B12 is low. Laboratory workup shows elevated serum methylmalonic acid (MMA) and elevated homocysteine. The enzyme marked **B** in the diagram is responsible for the elevation of MMA in this patient. Which of the following best explains why MMA is a more specific marker than homocysteine for distinguishing this patient's B12 deficiency from folate deficiency?
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