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    Subjects/Pathology/Wound Healing
    Wound Healing
    medium
    microscope Pathology

    A 32-year-old man sustained a laceration to his forearm during a knife injury 6 hours ago. The wound edges are clean and well-approximated. On examination, there is minimal contamination and no devitalized tissue. The patient's tetanus status is unknown. What is the most appropriate immediate next step in management?

    A. Observe the wound for 48 hours before deciding on closure to assess for infection
    B. Administer tetanus toxoid and proceed with primary closure after thorough irrigation and debridement
    C. Apply topical antibiotics and leave the wound open for secondary intention healing
    D. Refer to plastic surgery for closure without any immediate intervention

    Explanation

    ## Immediate Management of Clean Laceration ### Assessment of Wound Type This is a **clean laceration** with: - Clean wound edges (minimal contamination) - No devitalized tissue - Presented within 6 hours (golden period) - Good blood supply (forearm) ### Rationale for Primary Closure **Key Point:** Clean wounds presented within 6–12 hours of injury are ideal candidates for primary closure, which promotes faster healing with better cosmetic and functional outcomes. **High-Yield:** The three phases of wound healing are: 1. **Inflammatory phase** (0–3 days): hemostasis, inflammation, initial collagen deposition 2. **Proliferative phase** (3–21 days): angiogenesis, fibroblast activity, collagen synthesis 3. **Remodeling phase** (weeks to months): collagen cross-linking, scar maturation Primary closure initiated early maximizes the inflammatory phase benefits and minimizes scar formation. ### Tetanus Prophylaxis **Clinical Pearl:** Tetanus status is unknown → administer **tetanus toxoid** (not just TIG) as per standard protocol. This is a clean wound, so toxoid alone is sufficient if no prior immunization history is documented. ### Step-by-Step Approach | Step | Action | Rationale | |------|--------|----------| | 1 | Thorough irrigation | Remove debris, reduce bacterial load | | 2 | Debridement of devitalized tissue | Prevent infection, promote healing | | 3 | Tetanus prophylaxis | Prevent tetanus toxemia | | 4 | Primary closure (sutures/staples) | Optimal wound healing trajectory | | 5 | Dressing and follow-up | Monitor for complications | **Warning:** Delaying closure beyond 12 hours increases infection risk and shifts toward secondary intention healing, which is slower and produces worse scars.

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