Basal Cell Carcinoma

A 58-year-old man presents with a slowly growing, pearly nodule with central ulceration on his left cheek for the past 8 months. He has fair skin and a history of excessive sun exposure. On examination, the lesion shows rolled edges and a central crater. What is the investigation of choice to confirm the diagnosis?

Regarding the management and epidemiology of basal cell carcinoma, all of the following statements are correct EXCEPT:

A 68-year-old man presents with a slowly growing, painless nodule on the left cheek for 8 months. On examination, there is a 1.5 cm pearly nodule with central ulceration and rolled edges with telangiectasia. The lesion bleeds easily on minor trauma. Dermoscopy shows arborizing vessels. What is the most likely diagnosis?

The clinical image provided shows a skin lesion with characteristic features. Which of the following is the most likely diagnosis?

A 58-year-old woman with multiple basal cell carcinomas on her trunk and extremities (consistent with Gorlin syndrome) is not a surgical candidate due to comorbidities. Which systemic agent is the drug of choice for advanced or metastatic basal cell carcinoma in this setting?