Erythema Multiforme

A 32-year-old woman from Mumbai presents with a 3-day history of fever (38.5°C), severe oral ulceration, and painful erosions on her lips and buccal mucosa. She now has a widespread erythematous rash involving 25% of her body surface area with atypical lesions and blistering. She started taking trimethoprim-sulfamethoxazole (TMP-SMX) for a urinary tract infection 2 weeks ago. Her eyes are mildly injected. What is the most appropriate initial management?

A 28-year-old man from Delhi presents with a 5-day history of painful oral ulcers, followed by a symmetric rash on his palms and soles. On examination, he has target lesions with three distinct zones and erosions on the buccal mucosa. He reports a herpes simplex virus (HSV) infection 10 days prior. Laboratory investigations show normal complete blood count and liver function tests. What is the most likely diagnosis?

A patient presents with the skin lesions on the hand as shown in the image. Which of the following is the most likely diagnosis?

A 28-year-old woman presents with a 5-day history of painful oral ulcers and a pruritic rash on her palms and soles. Examination reveals target lesions with three distinct zones: a central blister, an erythematous middle ring, and a pale outer rim. She reports a herpes simplex virus infection 10 days prior. Temperature is 37.2°C, and there is no mucosal involvement beyond the oral ulcers. What is the most likely diagnosis?

A 35-year-old man presents with a 3-week history of fever (39.5°C), extensive oral ulceration, conjunctivitis with purulent discharge, and a widespread blistering rash affecting 25% of his body surface area. He denies recent infections but reports starting trimethoprim-sulfamethoxazole (TMP-SMX) for a urinary tract infection 2 weeks ago. Nikolsky sign is positive on unaffected skin. Histology shows full-thickness epidermal necrosis. What is the most likely diagnosis?