Keratoacanthoma

A 58-year-old male farmer from rural Maharashtra presents with a rapidly growing, flesh-colored nodule on the dorsum of his right hand that appeared 3 weeks ago. On examination, the lesion is 1.5 cm in diameter, dome-shaped, with a central keratin-filled crater and a rolled, indurated border. The surrounding skin shows solar elastosis. He reports no systemic symptoms. A shave biopsy shows well-differentiated squamous epithelium with central keratinization and a cup-shaped architecture. What is the most likely diagnosis?

A 62-year-old woman presents with a 2-week history of a rapidly enlarging, erythematous nodule on her left cheek. She reports that the lesion appeared suddenly and has been growing noticeably week by week. On examination, the lesion is 1.2 cm, firm, dome-shaped with a central depression filled with keratin material. There is mild surrounding erythema and the border is well-demarcated and rolled. She has a history of multiple solar keratoses on her face and neck. A punch biopsy shows a well-differentiated squamous epithelium with prominent central keratinization in a cup-shaped configuration. Which of the following is the most appropriate next step in management?

A 62-year-old woman from Bangalore presents with a solitary, rapidly enlarging nodule on her right ear that has grown from a small papule to 1.5 cm over 6 weeks. Clinically, the lesion is erythematous, dome-shaped with a central depression containing keratin material, and surrounded by a hyperkeratotic rim. Histopathology shows well-differentiated squamous epithelium with a central keratinous core, intact basement membrane, and minimal cytologic atypia. What is the most appropriate next step in management?

A 58-year-old man presents with a rapidly growing, flesh-colored nodule on the dorsum of his left hand that appeared 3 weeks ago. On examination, the lesion is 1.2 cm in diameter, dome-shaped, with a central keratin-filled crater and a raised, rolled border. The surrounding skin shows solar elastosis. He reports no pain or pruritus. A dermoscopic examination reveals a central white plug with peripheral erythema. What is the most likely diagnosis?