A 56-year-old machinist with 22 years of exposure to beryllium-copper alloy presents with progressive exertional dyspnea, non-productive cough, and bibasilar crackles. Chest CT shows diffuse parenchymal nodules, reticulation, and honeycombing. Beryllium lymphocyte proliferation test (BeLPT) is markedly positive. Pulmonary function testing reveals FEV1 2.10 L (62% predicted), FVC 2.55 L (60% predicted), FEV1/FVC ratio 0.82 (preserved), TLC 4.20 L (62% predicted), and DLCO 11.8 mL/min/mmHg (40% predicted). The flow-volume loop is miniaturized with preserved peak expiratory flow and sharp descending limb. The pattern marked **A** in the diagram represents which of the following pulmonary function abnormalities?
Ready to test yourself?
Test your Medicine knowledge with AI-powered MCQs and detailed explanations — no signup required to try.
Sign up free and practice all 1 Chronic Beryllium Disease MCQs with AI-powered explanations tailored to your performance.
Create Free Account