A 42-year-old male presents with progressive dysphagia to solids over 6 months and a recent episode of food impaction requiring emergent endoscopic removal. Upper endoscopy reveals the findings marked **A** in the diagram: concentric rings with linear furrows and white exudates. Esophageal biopsies from proximal and distal esophagus show 28 eosinophils per high-power field. Which of the following best describes the pathophysiologic mechanism underlying this patient's condition?
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