A 16-year-old boy of Armenian descent presents with recurrent self-limited attacks of high fever (39–40°C), acute abdominal pain mimicking appendicitis, and sterile peritonitis occurring every 4–6 weeks. Between attacks he is completely well. His parents are consanguineous. Genetic testing confirms biallelic mutations in the MEFV gene marked **A** in the diagram. Which of the following best explains the pathophysiological mechanism underlying his recurrent inflammatory attacks?
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