A 58-year-old Indian woman presents with a 2-year history of progressive iron deficiency anemia (Hb 7.2 g/dL) and recurrent melena. She reports a lifelong history of spontaneous recurrent epistaxis since childhood and multiple small red spots on her lips and fingertips. Upper endoscopy and colonoscopy were unrevealing. Video capsule endoscopy reveals multiple small bowel telangiectasias as shown in the diagram (marked **A**). Genetic testing confirms a heterozygous mutation in the ENG gene. Which of the following best explains the pathophysiology of the vascular lesions marked **A** in this patient?
Ready to test yourself?
Test your Medicine knowledge with AI-powered MCQs and detailed explanations — no signup required to try.
Sign up free and practice all 1 HHT Small Bowel AVMs MCQs with AI-powered explanations tailored to your performance.
Create Free Account