A 62-year-old postmenopausal woman presents with vaginal bleeding for 2 months. Transvaginal ultrasound shows an endometrial thickness of 8 mm with a polypoid mass. Histology confirms endometrial adenocarcinoma. The structure marked **B** in the diagram shows a polypoid endometrial mass with myometrial invasion. Which of the following molecular/genetic profiles is MOST COMMONLY associated with this type of endometrial carcinoma in this patient?
A 62-year-old obese (BMI 38), nulliparous, postmenopausal woman presents with painless postmenopausal bleeding for 6 weeks. Transvaginal ultrasound shows an endometrial stripe of 14 mm. Endometrial biopsy reveals well-differentiated endometrioid adenocarcinoma, FIGO grade 1. Hysterectomy specimen demonstrates the structure marked **A** in the diagram — a polypoid, friable, tan-white mass arising from the endometrium and projecting into the cavity, with focal superficial myometrial invasion (<50% myometrial thickness). Which of the following best describes the pathogenesis and molecular basis of this tumor type?
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