A 16-year-old boy presents with progressive central vision loss over the past 2 years and difficulty reading. Fundoscopy reveals bilateral macular atrophy with yellow pisciform flecks at the posterior pole, as marked **A** in the diagram. Fluorescein angiography shows a dark choroid sign. Which of the following genetic mutations is most likely responsible for this presentation?
A 14-year-old boy presents with progressive bilateral central vision loss over the past 2 years, now measuring 20/100 in each eye. Fundoscopy reveals a beaten-bronze macular appearance with characteristic yellow-white pisciform flecks in the posterior pole. Fundus autofluorescence shows hyperautofluorescent flecks with central hypoautofluorescence and a hyperautofluorescent ring at the disease frontier. The structure marked **B** in the diagram represents the most likely diagnosis. Which of the following genetic mutations is responsible for the photoreceptor and RPE degeneration seen in this condition?
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