Giant Cell Tumor

A 32-year-old man with a known giant cell tumor of the distal femur is being evaluated for surgical planning. Plain radiographs and MRI have been completed. Which additional investigation is most appropriate to assess for malignant transformation and determine the aggressiveness of the lesion?

Giant cell tumor of bone most commonly arises in which anatomical location?

A 32-year-old man with a history of giant cell tumor of the distal femur treated with intralesional curettage and bone grafting 3 years ago now presents with a recurrent lytic lesion at the same site. Imaging shows local recurrence without distant metastases. He is counseled about treatment options. Which of the following is the most appropriate next step in management?

A 32-year-old man with a known giant cell tumor of the distal femur underwent curettage 18 months ago. He now presents with recurrent pain and swelling over the same site. Repeat radiographs show a new lytic lesion at the previous surgical site with a similar soap bubble pattern. Histology confirms recurrent GCT. Which of the following adjuvant techniques would have been most effective in reducing recurrence risk at the time of initial surgery?

A 28-year-old woman presents with pain and swelling in the right knee for 3 months. Clinical examination reveals a tender swelling over the distal femur just above the knee joint. Plain radiographs show a lytic lesion in the epiphyseal-metaphyseal region with a narrow zone of transition. Which investigation is most appropriate to confirm the diagnosis of giant cell tumor of bone?