Aplastic Anemia

A 35-year-old man presents to the hematology clinic with a 2-month history of progressive weakness and petechial rash. He reports a severe bout of hepatitis A infection 6 weeks prior, from which he has clinically recovered. Current labs show Hb 8.5 g/dL, WBC 1,800/μL, platelets 28,000/μL, reticulocyte count 0.5%, and normal liver function tests. Bone marrow examination reveals 10% cellularity with normoblasts, myeloid precursors, and megakaryocytes all reduced proportionally. Flow cytometry shows no abnormal populations. Cytogenetics are normal. What is the most likely diagnosis?

A 28-year-old woman from rural Maharashtra presents with a 3-month history of progressive fatigue, dyspnea on exertion, and recurrent oral ulcers. She denies fever, weight loss, or bleeding manifestations. On examination, she is pale with mild hepatosplenomegaly. Laboratory investigations reveal hemoglobin 7.2 g/dL, WBC 2,100/μL, platelets 45,000/μL, reticulocyte count 0.8%, and serum iron 180 μg/dL with elevated ferritin. Bone marrow biopsy shows hypocellular marrow (cellularity 15%) with no dysplasia, fibrosis, or malignant infiltration. What is the most likely diagnosis?

Which of the following is the most common acquired cause of aplastic anemia in India?

In aplastic anemia, which of the following bone marrow findings is diagnostic?