3 MCQs in Pathology for NEET PG
A 32-year-old woman presents to the emergency department with acute onset of severe itching, facial flushing, and urticaria 15 minutes after a bee sting on her forearm. Her blood pressure is 95/60 mmHg, heart rate 118/min, and she has audible wheezing. A skin biopsy from an urticarial lesion shows mast cell degranulation. Which of the following mediators released from mast cells is primarily responsible for the vasodilation and increased vascular permeability observed in this patient?
A 28-year-old man with a history of chronic inflammatory bowel disease (Crohn's disease) presents with acute exacerbation: severe diarrhea, abdominal cramping, and bloody stools for 3 days. Colonoscopy shows transmural inflammation with ulceration. Histology reveals increased neutrophilic infiltration and elevated levels of leukotriene B4 (LTB4) in the inflamed mucosa. Which of the following best explains the role of LTB4 in perpetuating this inflammatory response?
Which of the following chemical mediators is a preformed mediator stored in mast cell and basophil granules?
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