A 28-year-old man presents with a 6-month history of chronic diarrhea, right lower quadrant abdominal pain, and a 4 kg weight loss. Ileocolonoscopy with biopsy reveals non-caseating granulomas and transmural inflammation. On contrast-enhanced CT enterography, the terminal ileum shows a markedly thickened, rigid wall with a severely narrowed lumen, creating the appearance shown as structure **A** in the diagram. Which of the following best explains why this morphological change occurs in Crohn disease but NOT in ulcerative colitis?
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