2 MCQs in Pathology for NEET PG
The peripheral blood smear shown above reveals numerous red blood cells with absent central pallor and a spherical shape. This morphology is most characteristic of which of the following conditions?
A 7-year-old boy presents with jaundice, mild anaemia, and splenomegaly. His father and paternal grandfather are similarly affected, and his father's brother is unaffected. The pedigree shows affected individuals in every generation with clear male-to-male transmission. A peripheral blood smear shows spherocytes, and the direct Coombs test is negative. The EMA binding test confirms the diagnosis. Which inheritance pattern, marked as **A** in the pedigree diagram, best explains this family's presentation of hereditary spherocytosis?
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