A 6-year-old boy of Ashkenazi Jewish descent presents with severe short stature (height 100 cm), photosensitive malar telangiectatic erythema, and recurrent sinopulmonary infections. Cytogenetic analysis reveals the abnormality marked **B** in the diagram — quadriradial chromosomal configurations with a 10-fold increase in sister chromatid exchanges. Which of the following molecular defects best explains this cytogenetic finding?
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