A 2-day-old term male infant presents with abdominal distention, bilious vomiting, and failure to pass meconium. Contrast enema shows a narrow distal colonic segment (marked **C** in the diagram) with a transition zone to a dilated proximal colon. Rectal suction biopsy of the narrow segment confirms absence of ganglion cells in both Meissner and Auerbach plexuses. Which of the following best explains the pathophysiology of the narrow distal segment marked **C**?
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