A 4-year-old boy presents with 8 fractures from minor trauma over 2 years. Clinical examination reveals blue sclerae, opalescent teeth, and short stature. Radiographs show multiple long-bone fractures at various stages of healing with abundant callus formation, generalized osteopenia, anterolateral bowing of the femur and tibia, and numerous wormian bones in the skull. The condition marked **A** in the diagram is suspected. Which of the following genetic mutations is most commonly responsible for this disorder?
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